. 2016 Nov 8;6:35371. doi: 10.1038/srep35371

Table 2. Most significant interactions associated with AF (P < 5 × 10⁻⁷).

AF SNP		Interacting SNP							Interaction effects			Replication
SNP	Closest gene	SNP	Locus	Closest gene	Location	Coding allele	CAF^$	Meta P value	OR^⁺	95% CI^{^*}	P value	OR^⁺	95% CI^{^*}	P value
rs7164883	HCN4	rs4980345	15q25.3	SLC28A1	Intron	T	0.06	0.78	1.44	1.27–1.65	4.3 × 10⁻⁸	0.94	0.74–1.20	0.64
rs10821415	C9orf3	rs1492056	3p14.1	MITF	Intergenic	A	0.43	0.37	1.15	1.09–1.21	1.4 × 10⁻⁷	0.91	0.84–0.99	0.04
rs12415501	NEURL	rs699801	1p31.1	CRYZ	Intergenic	T	0.45	0.83	1.19	1.12–1.27	1.9 × 10⁻⁷	1.01	0.90–1.13	0.91
rs2106261	ZFHX3	rs12652090	5q34	TENM2	Intergenic	A	0.11	0.43	1.31	1.18–1.45	2.1 × 10⁻⁷	1.02	0.87–1.20	0.80
rs1448818	PITX2 (2)	rs693832	8p21.1	MIR3622B	Intergenic	C	0.11	0.36	1.27	1.16–1.39	3.1 × 10⁻⁷	1.03	0.89–1.19	0.72
rs3807989	CAV1	rs3802477	9q22.33	GABBR2	Intron	C	0.05	0.30	1.35	1.20–1.52	3.6 × 10⁻⁷	1.05	0.86–1.27	0.64
rs3807989	CAV1	rs2327995	6p22.3	ATXN1	Intron	G	0.27	0.74	1.15	1.09–1.22	4.3 × 10⁻⁷	1.05	0.95–1.15	0.32
rs1448818	PITX2 (2)	rs2328452	20p11.23	RIN2	Intergenic	G	0.88	0.92	1.25	1.15–1.37	4.7 × 10⁻⁷	0.94	0.82–1.08	0.37
rs12415501	NEURL	rs7946907	11p15.2	SPON1	Intron	A	0.54	0.05	1.18	1.11–1.26	4.7 × 10⁻⁷	1.07	0.96–1.20	0.23

^$CAF: coding allele frequency; ⁺OR: odds ratio; ^*CI: confidence interval.

Table 2. Most significant interactions associated with AF (P < 5 × 10−7).