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. 2016 Nov 8;6:35533. doi: 10.1038/srep35533

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A,B) KBM5, KBM5-T315I, 32D-p210 and 32D-T315I cells were treated with 0.3 μM of AKI603 for 48 h or 96 h, and senescence was determined using SA-β-gal staining. (C,D) The statistical analysis of the SA-β-gal assay is shown. More than 300 cells per sample were counted to determine the percentage of senescent cells (mean ± SD, *p < 0.05, **p < 0.01 vs. 0). (E) KBM5, KBM5-T315I, 32D-p210 and 32D-T315I cells were treated with 0.3 μM and 0.6 μM of AKI603 for 96 h. The lysates were subjected to western blot to analyze the expression of p53 and p21. The data are representative of three independent experiments.