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. 2015 Jun 18;16(3):034610. doi: 10.1088/1468-6996/16/3/034610

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© 2015 National Institute for Materials Science

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Figure 4. — (a) TEM image of Au@SiO₂ nanocarrier. (b) Influence of photothermal approach on cell sensitivity to DOX by a 780 nm fs-pulse laser irradiation at 3.2 W cm⁻² for 12 min. Before NIR irradiation, MCF-7/ADR cells were exposed to 30 μg mL⁻¹ Au@SiO₂ in cell culture medium for 24 h. (c) Mechanisms of the reversal of drug resistance of cancer cells under fs-pulse laser irradiation. Photothermal stimulus triggers the activation of heat shock factor (HSF-1) to depress NF-κB pathway that dominates in the regulation in the characteristics of drug resistance. As a result, NIR irradiation modulates cell-signaling pathways to increase the sensitivity of MCF-7/ADR to doxorubicin (DOX) as well as to enhance the DOX accumulation. Reprinted with permission from [114]. Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.