Table 1. Comparison with the reported state-of-art electrochemical platforms for miRNA detection.
Detection Method | Electrode Surface | MicroRNA | LOD | Reference |
---|---|---|---|---|
CV & EIS | Gold electrode | miR-21 | 3.96 pM | Zhou et al.39 |
DPV & EIS | Gold electrode modified with AuNP | miR-21 | 6 fM | Meng et al.40 |
CV & DPV | Gold electrode | miR-21 | 45 fM | Xia et al.41 |
EIS | Gold electrode and duplex specific nuclease as an amplification tool | let-7a, let-7b, let-7c | 1 fM | Ren et al.42 |
DPV & EIS | Gold electrode modified with AuNP | miR-159a | 3.5 fM | Wang et al.43 |
CV | Gold electrode | miR-21 | 3 fM | Liu et al.44 |
DPV & EIS | Gold electrode | let-7a, let-7b, let-7c | 99.2 fM | Peng et al.45 |
CV, DPV & EIS | Gold electrode modified with AuNPs | miR-21 | 0.17 fM | Wang et al.46 |
DPV | Gold electrode modified with AuNP | miR-139a | 1.7 fM | Zhou et al.47 |
DPV | Gold electrode modified with AuNP | miR-21 | 0.36 fM | Li et al.48 |
EIS & SWV | Gold Electrode | mir145 | 0.37 fM | This study |
CV: Cyclic voltammetry; DPV: Differential Pulse Voltammetry; EIS: Electrochemical Impedance Spectroscopy; SWV: Square Wave Voltammetry.