Table 4.
Phytochemicals which are cytotoxic against cancer cell lines.
| Phytochemical(s) | Cell line | References |
|---|---|---|
| Actein (Actaea racemosa) | HepG2 (liver cancer), MCF7 (breast cancer) | Einbonda et al., 2009 |
| β-Aescin (Aesculus hippocastanum) | HT29 (colorectal adenocarcinoma) | Zhang et al., 2010 |
| Allylmercaptocysteine, allicin (Allium sativum) | HeLa (cervix cancer), L5178Y (lymphoma), MCF7 | Karmakar et al., 2011 |
| Amooranin (Amoora rohituka) | MCF7, CEM (lymphocytic leukemia) | Chan et al., 2011 |
| Asiatic acid (Centella asiatica) | EAC (ehrlich ascites carcinoma), DLA (dalton's lymphoma ascites), SK-MEL-2 (melanoma), U-87-MG (glioblastoma), B16F1 (melanoma), MDA-MB-231 (breast adenocarcinoma) | Heidari et al., 2012 |
| Baicalein (Scutellaria baicalensis) | LXFL-529L (lung cancer) | Zhou et al., 2008 |
| Carnosic acid, rosmarinic acid (Rosmarinus officinalis) | A549 (lung cancer), SMMC7721 (liver cancer), A2780 (ovary cancer) | Tai et al., 2012 |
| β-Caryophyllene, α-zingiberene (Peristrophe bicalyculata) | MCF7, MDA-MB-468 | Ogunwande et al., 2010 |
| Cinnamaldehyde (Cinnamomum zeylanicum) | HeLa, HCT116 (colorectal carcinoma), HT29 | Koppikar et al., 2010 |
| Clausenalansamide A and B (Clausena lansium) | SGC-7901 (gastric cancer), HepG2, A549 | Maneerat et al., 2011 |
| Corydine, salutaridine (Croton macrobotrys) | NCI-H460 (lung cancer), K5662 (leukemia) | Motta et al., 2011 |
| Conyzapyranone A and B (Conyza Canadensis) | HeLa, A431 (epidermoid carcinoma), MCF7 | Csupor-Loffler et al., 2011 |
| Costunolide, tulipinolide, liriodenine, germacranolide (Liriodendron tulipifera) | KB (oral cancer), HT29 | Wang et al., 2012 |
| Crocin, picrocrocin, crocetin, and safranal (Crocus sativus) | S-180 (sarcoma), EAC, DLA, Tca8113 (oral cancer), and HCT116 | Bakshi et al., 2009 |
| Dioscin (Dioscorea colletti) | HepG2, SGC-7901 | Hu et al., 2011 |
| Epicatechin, procyanidin B2, B4 (Litchi cinensis) | MCF7 | Bhoopat et al., 2011 |
| Gallic acid (Leea indica) | EAC | Raihan et al., 2012 |
| Harringtonines (Cephalotaxus harringtonia) | P388 (blood cancer), L-1210 (blood cancer) | Jin et al., 2010 |
| Hydroxycinnamoyl ursolic acid (Vaccinium macrocarpon) | MCF7, ME180 (cervical cancer), and PC3 (prostate cancer) | Kondo et al., 2011 |
| Leachianone A (Radix sophorae) | HepG2 | Long et al., 2009 |
| Lectin (Hibiscus mutabilis) | HepG2, MCF7 | Lam and Ng, 2009 |
| Naphthoquinones (Tabebuia avellanedae) | EAC, DU145 (prostate cancer) | Yamashita et al., 2009 |
| Niazinine A (Moringa oliefera) | AML (blood cancer), HepG2 | Khalafalla et al., 2011 |
| Pectolinarin (Cirsium japonicum) | S180, H22 (liver cancer) | Yin et al., 2008 |
| Piperine, piperidine (Piper nigrum) | B16F10 (melanoma) | Liu et al., 2010 |
| Platycodin D (Platycodon grandiflorum) | A549, HT29 | Shin et al., 2009 |
| Plumbagin (Plumbago zeylanica) | PC3, A549, NB4 (blood cancer), A375 (skin cancer), SGC7901 | Checker et al., 2010 |
| Pyrogallol (Emblica officinalis) | L929 | Baliga and Dsouza, 2011 |
| Tylophorine (Tylophora indica) | A549, DU145, ZR751 (breast cancer) | Kaur et al., 2011 |
| Withaferin A (Withania somnifera) | MCF7, MDA-MB-231 | Hahm et al., 2011 |