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. 2016 Nov 8;6:36572. doi: 10.1038/srep36572

Figure 1. Chromatin Interaction Networks (ChINs) involving non-coding RNAs and protein-coding genes in K562.

Figure 1

(A) The largest sub-network (as giant component) of ChIN. The different colors of the nodes represent different chromosomes (refer to Supplementary Table S3). Certain known lncRNAs are labeled with arrows. (B) Venn diagrams of the different types of genes in the ChINs of the K562 and MCF7 cells. (C) Box plots of degrees from the different types of genes in the ChIN. (D–F) Examples of lincRNA genes in categories C1–C3. (D) Category C1 (TERC interacts with some protein-coding genes), (E) C2 (RP11-671C19.1 interacts with lincRNA genes other than protein-coding genes) and (F) C3 (AC073236.3 interacts with non-promoter elements). Categories C1–C5 are defined in (G). (G) Definitions of the different categories of lincRNAs (C1–C5) and the numbers of lincRNAs in each category. All of the overlaps of the five categories are significant. (p-value < 0.001, Fisher Exact Test). (H). RNAPII signal intensities (log2 transformed) of lincRNA genes in different interaction categories.