Table 2. Changes induced in the PWR resonance position upon ligand addition to the CCR5 StaR reconstituted in a POPC, POPC/Chol (8/2 mol/mol) and POPC/SM/Chol (6/2/2 mol/mol/mol) and dissociation constants for the receptor/ligand interaction.
| p-pol shifts (mdeg) | s-pol shifts (mdeg) | KD (nm) | |
|---|---|---|---|
| POPC | 10 ± 2 | 9 ± 2 | 5.3 ± 0.5 |
| POPC/Chol | 4 ± 1 | 1.5 ± 0.5 | 1.2 ± 0.3 |
| POPC/SM/Chol | 3 ± 1 | 1 ± 0.5 | 1.4 ± 0.4 |
Note: The average values and the SD from the mean were obtained from a total of 3 independent experiments.