Figure 1. Work flow with the key filtering and processing steps applied to generate the final set of drug-target–tissue combinations investigated in this study.

(A) Gold standard set of gene-disease relationships obtained by extracting all genes and their disease indications that are currently in Phase III or marketed as per the drug industry pipeline. (B) Generate a MAS score to assess the connection between a particular disease and tissue. (C) Mapping the relevant tissues to each drug-disease pair.