Table 3. List of targets shared between two different disease classes.

Disease Ontology 1	Disease Ontology 2	Shared Targets	Targets
nervous system disease	cardiovascular system disease	23	ADRA1A;ADRA2A;ADRB1;AVPR2;CA2;CACNA1C;HMGCR;HTR2A;IL1B;INSR;MS4A1;MTOR;NR3C1;PDE5A;PLG;PPARG;PPIA;PTGER1;SLC12A3;SLC6A4;TBXAS1;TNF;VEGFA;
nervous system disease	disease of metabolism	12	AKR1B1;AVPR2;CNR1;CUBN;DRD2;HMGCR;IL1B;INSR;NR3C1;PGR;PPARG;SLC6A4;
disease of metabolism	cardiovascular system disease	17	ACE;AGTR1;AVPR2;CETP;HCAR2;HMGCR;IL1B;INSR;LPL;NR3C1;PDE3A;PPARG;SLC22A12;SLC5A2;SLC6A2;SLC6A4;XDH;

The complete list of all shared targets between all disease classes can be found in Supplementary Table S4.