Table 2. Association analyses between amygdala activity in the Negative Faces > Shapes contrast and oxytocin receptor polymorphisms.
SNP | Amygdala hemisphere | SCZ n=104 | AD n=100 | HC n=142 | Total N=346 | ||||
---|---|---|---|---|---|---|---|---|---|
Effect size | P | Effect size | P | Effect size | P | Effect size | P | ||
Rs2254298 (G)a | Left | b=0.12 | 0.97 | b=−1.35 | 0.67 | b=1.92 | 0.40 | b=0.72 | 0.66 |
Right | b=−1.11 | 0.77 | b=4.24 | 0.20 | b=0.45 | 0.84 | b=1.22 | 0.47 | |
Rs53576 (G) | Left | b=4.93 | 0.026 | b=0.37 | 0.87 | b=−3.36 | 0.06 | b=0.35 | 0.77 |
Right | b=3.28 | 0.19 | b=0.69 | 0.77 | b=−1.14 | 0.50 | b=0.77 | 0.54 | |
Rs237902 (G) | Left | b=−4.99 | 0.014b | b=−0.25 | 0.90 | b=2.81 | 0.08 | b=−0.56 | 0.59 |
Right | b=−3.84 | 0.097 | b=−2.66 | 0.18 | b=2.65 | 0.08 | b=−1.00 | 0.36 |
SNP, single nucleotide polymorphism; SCZ, schizophrenia spectrum disorders; AD, affective spectrum disorders; HC, healthy controls.
Results for the G allele dosage are displayed.
Remains significant after Bonferroni corrections (3 independent tests).