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. 2016 Nov 8;16:434. doi: 10.1186/s12906-016-1389-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mouse livers stained with TIMP-2 and Bax antibodies (a and b, respectively). a: Control group, with negative (−ve) TIMP-2 and Bax immunoreactivity in the hepatocytes and central vein. b: Vehicle control group, with negative (−ve) TIMP-2 immunoreactivity in the hepatocytes and strong positive (+ve) Bax immunoreactivity in hepatic tissues. c: PZQ (500 mg/kg bwt)-treated group, with mild TIMP-2 immunoreactivity and strong positive (+ve) Bax immunoreactivity in the hepatic tissues adjacent to the granuloma. d: CPE (300 mg/kg bwt)-treated group, showing positive (+ve) TIMP-2 immunoreactivity in the hepatic tissues surrounding the granuloma and mild Bax immunoreactivity in the hepatocytes adjacent to the fibrous granuloma. e: CPE (600 mg/kg bwt)-treated group, with positive (+ve) TIMP-2 immunoreactivity and weak Bax immunoreactivity in the hepatocytes adjacent to the fibrous granuloma (×400)