Table 2.
Groups | Mean number of worms ± SEM | Reduction on worm burden (%) | Ova count in liver ± SEM | Reduction on ova count (%) | Granuloma size (μm2) |
---|---|---|---|---|---|
Vehicle control | 15.3 ± 1.37 | - | 11.4 ± 1.08 | - | 968500 ± 1364 |
PZQ (500 mg/kg bwt) | 4.7 ± 0.52a | 69.5a | 2.3 ± 0.71a | 79.8a | 915400 ± 1519 |
CPE (300 mg/kg bwt) | 9.3 ± 1.36a | 39.0a | 5.7 ± 0.34a | 50.0a | 882200 ± 757a |
CPE (600 mg/kg bwt) | 7.0 ± 0.89a | 54.2a | 3.1 ± 0.28a | 72.8a | 808900 ± 361a |
Values are means ± SEM (n = 5). a p < 0.05, significant change with respect to the Vehicle control