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. 2016 Nov 8;11:128. doi: 10.1186/s13000-016-0580-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Variation in microvessel density among tumors. Legend: a In this tumor, there are few CD31-positive endothelial cells and the tumor has an extremely low microvessel density. No venous invasion was observable (immunohistochemistry for CD31; original magnification, ×100, scale; bar represents 100 μm). b In this tumor, numerous CD31-positive endothelial cells were observable and the tumor has a high microvessel density. This is representative of most of cases with venous invasion (immunohistochemistry for CD31; original magnification, ×100; scale bar represents 100 μm)