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. 2016 Oct 21;7:42. doi: 10.4103/2153-3539.192810

Figure 1.

Figure 1

Overview of the nuclei detection and segmentation procedure. The nuclei seeds are firstly detected using a set of filters with different sizes. An edge pyramid is then constructed, where edge maps are generated using a set of smooth parameters. Edge selection is performed at each level and the nuclei contour evolves across the edge pyramid to delineate the spatial content of cell nuclei