Fig. 3.

CHI3L1 levels positively correlate with the frequency of CD161+ cells in the SF of JIA. PB and SF from 25 JIA patients were evaluated: sera from peripheral blood (white columns) and SF (black columns) were obtained and CHI3L1 amounts evaluated by ELISA (a). Columns represent mean values (±SE). *p ≤ 0.05. MNC cells obtained from SF were characterized by flow cytometry and correlation between CHI3L1 levels in SF and frequency of CD4+CD161+IL17+ cells (b), CD4+CD161+IFNγ+ cells (c) and CD4+CD161−IFNγ+ cells (d), in SF, was represented. e Correlation between CHI3L1 levels in SF and CRP serum levels in the same group of patients. f The indicated cytokines were assessed in the sera (white columns) and SF (black columns) from 25 JIA patients. Columns represent the mean values (±SE). *p ≤ 0.05. g Correlation between CHI3L1 levels in SF and IL6 (left panel) or p40 (right panel) SF levels in the same group of patients, was represented