Table 1.

List of C. elegans genes that carry significant mutations in the EAB135 suppressors identified from the screen based on slow movement.

C. elegans gene/chromosome	Human ortholog/homolog	Protein and function	Position	Codon change	Transcritional/translational prediction
EAB164
acp-4/II	ACP2, ACPT, ACPP	Lysosomal acid phosphatase activity	8434143	CGA>TGA	STOP
ugt-42/V	UGT3A1,UGT3A2	Transferase activity, transferring hexosyl groups	648416	GT>AT	TAA introduced
F57A10.2/V	VAPA, VAPB		15766903	TCA>TGA	STOP
EAB165
nhr-181/V	HNF4G	A putative nuclear hormone receptor (NHR)	4097868	AG>AA*	Frame shift
F57A10.2/V	VAPA, VAPB		15766903	TCA>TGA	STOP
EAB167
T10E9.2/I			6543341	TCA>TAA	STOP
str-46/V		7 transmembrane GPCR, serpentine receptor class r (Str)	2899516	TGG>TGA	STOP
F57A10.2/V	VAPA, VAPB		15766903	TCA>TGA	STOP
dnj-25/V	auxilin	Required for clathrin-mediated endocytosis and for normal development	20743985	AG>AT*	PE deletion, frame might not shift
mrp-2/X	MRP1, MRP2	A predicted multidomain transmembrane protein that is a member of the ATP-binding cassette superfamily of transport proteins	569906	TGG>TGA	STOP

^*Splicing site. ACPT, acid phosphatase, testicular; ACPP, acid phosphatase, prostate; ACP2, acid phosphatase 2, lysosomal; UGT3A1, UDP glycosyltransferase 3 family, polypeptide A1; UGT3A2, UDP glycosyltransferase 3 family, polypeptide A2; VAPA/B, vesicle-associated membrane protein-associated protein A/B; HNF4G, isoform 2 of hepatocyte nuclear factor 4-gamma; MRP1, multidrug resistance-associated protein 1; Dnj-25 is a potential model for Parkinson's disease.