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Genomic organization of the m4C/m6A Type I R-M system genes. M1:m6A indicates the m6A MTase subunit and M2:m4C indicates the m4C MTase subunit. The C (cytosine) that is methylated to m4C is boxed, as is the T (thymine) that pairs with the adenine that is methylated in the opposite strand. In these 10 systems the spacing between the methylated bases is conserved at 7 base pairs. Grey arrows indicate genes that are not part of the RM system.
