. 2016 Sep 28;6(11):7448–7451. doi: 10.1021/acscatal.6b02114

Table 3. Gram-Scale Synthesis of Allenyl Acetates from Propargyl Substrates^a.

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Isolated yields. Conditions: 0.1 M solution of substrate 7 or 9 (1.25–2.25 g, 1 equiv), R⁴ MgX (1.25 equiv), and 1 mol % of Fe(acac)₃ in Et₂O, addition of R⁴ MgX for 5 and 10 min reaction time.

5 mol % of Fe(acac)₃, R⁴ MgX (1.5 equiv).

7.5 mol % of Fe(acac)₃, R⁴ MgX (1.75 equiv).

half gram-scale.

10 mol % of Fe(acac)₃, BnMgX (2.5 equiv).

by 2 steps.

Table 3. Gram-Scale Synthesis of Allenyl Acetates from Propargyl Substratesa.

Table 3. Gram-Scale Synthesis of Allenyl Acetates from Propargyl Substrates^a.