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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Colloids Surf B Biointerfaces. 2016 Mar 26;144:8–20. doi: 10.1016/j.colsurfb.2016.03.071

Figure 1. Physico-chemical characterization of SPION-Dtxl.

Figure 1

A) Schematic preparative approach and hypothetical structure of SPION-Dtxl formulation. Color and dimensions are not comparable to original formulation. Docetaxel resides in β-cyclodextrin and/or pluronic F127 polymer layers. B) Representative transmission electron microscopic image of SPION-Dtxl. Scale bars on TEM images equal 100 nm. Individual grain of SPION is about 8–10 nm. Size of aggregated SPION-Dtxl ~100 nm. Direct Mag: 100,000X, obtained using AMT camera system. C–D) Particle size and zeta potential of SPION and SPION-Dtxl in water and serum. Note: A slight increase of particle size and zeta potentials was noticed in serum over water. Data represented as mean ± SEM (n = 3). E) FT-IR spectra of Dtxl, SPION and SPION-Dtxl. F) Thermogravimetric analysis of SPION and SPION-Dtxl. Dtxl loading in SPION (SPION-Dtxl) resulted in greater (~9.5–10%) weight compared to SPION. G) X-ray diffraction patterns of SPION and SPION-Dtxl. No significant change in patterns indicated successful entrapment of Dtxl in β-CD and pluronic F127 polymer layers.