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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Colloids Surf B Biointerfaces. 2016 Mar 26;144:8–20. doi: 10.1016/j.colsurfb.2016.03.071

Figure 8. J591-SPION-Dtxl formulation targets PSMA+ PC tumors.

Figure 8

J591-SPION-Dtxl specifically targets A) C4-2 orthotopic and subcutaneous xenograft (PSMA+) tumors tissues, but not B) PC-3 orthotropic xenograft (PSMA−) tumor tissues. Histological tissue sections were treated with Coumarin 6 loaded SPION-Dtxl (untargeted NPs) or J591-SPION-Dtxl (targeted NPs) and processed slides were visualized under confocal microscope. Original magnification 400X (Bar = 4 μm). C) Quantitative measurement of cell fluorescence of SPION-Dtxl (untargeted NPs) or J591-SPION-Dtxl (targeted NPs) in tumor tissues through CTCF intensity using ImageJ Software. Fluorescence data represent mean ± SEM; n = 40 cells from 5 tissue slide images; *p < 0.05.