Figure 3. Time course of Unified Parkinson’s Disease Rating Scale (UPDRS) part III and Hamilton Depression Rating Scale (HAM-D) scores by treatment group.

Lack of improvement in motor or mood symptoms after combined M1 + DLPFC rTMS vs sham. There was no significant improvement in motor (A and B) or mood (C and D) symptoms after combined M1 + dorsolateral prefrontal cortex (DLPFC)repetitive transcranial magnetic stimulation (rTMS) vs sham. There was also no added benefit of M1 + DLPFC stimulation on motor symptoms compared to M1 stimulation alone (A and B) or mood benefit compared to DLPFC alone (C and D).