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Potencies for inhibiting D2, D3 and D4 receptor function by buspirone and its metabolites
| D2 IC50±S.E.M. (n) |
D3 IC50±S.E.M. (n) |
D4 IC50±S.E.M. (n) |
|
|---|---|---|---|
| Buspirone | 0.67±0.12 (7) | 0.44±0.18 (7) | 0.35±0.06 (6) |
| 5-OH Buspirone | 2.6±1.3 (4) | 0.93±0.46 (4) | 1.4±0.82 (3) |
| 6-OH Buspirone | 3.1±1.8 (4) | 4.9±2.8 (3) | 0.85±0.49 (3) |
| 1-PP | >10 | >10 | >10 |
