Table 3.

Dose-ranging studies: effects of pretreatment with i.m. buspirone on i.v. cocaine self-administration and food-maintained behaviour

Monkey	Buspirone (mg/kg)	1 Inj	2 Inj	3 Inj	4 Inj	Total Inj	Food 1 Pellets	Food 2 Pellets
RIB9		12 (±1)	8 (±1)	8 (±1)	7 (±1)	35 (± 1)	14 (± 1)	16 (±0)
	0.03	14	13	14	13	54	16	15
	0.10	14	8	2	0	24	15	14
	0.32	0	0	0	0	0	16	13
97D105		9 (±1)	7 (±0)	6 (±0)	6 (±0)	28 (± 1)	16 (± 0)	1 (±1)
	0.10	0	10	10	5	25	12	0
	0.32	0	0	0	0	0	7	13
97D113		11 (±2)	5 (±1)	5 (±1)	5 (±1)	25 (± 2)	18 (± 0)	4 (±3)
	0.03	11	10	7	3	31	17	0
	0.10	14	13	7	6	40	18	0
	0.32	0	0	0	0	0	0	1
96D155		13 (±3)	12 (±1)	11 (±1)	10 (±2)	46 (± 4)	17 (± 0)	9 (±3)
	0.03	1	0	0	6	7	17	17
	0.10	0	0	0	0	0	17	17
	0.32	0	0	0	0	0	0	16

Data under 1, 2, 3 and 4 show numbers of injections (Inj) self-administered during the availability of the unit dose of 0.03 mg/kg per injection of cocaine during the four successive 25-min segments of the self-administration component alone (shown in bold) and following a range of pretreatment doses of buspirone.

The last two columns show number of pellets obtained in components of food-maintained behaviour prior to (food 1) and following (food 2) the drug component when cocaine was available for i.v. self-administration.

Values for the number of injections for cocaine alone are averaged data (mean±S.E.M.) obtained during the present assessments.