Table 4.
Number of injections: effects of pre-session administration of buspirone on total number of i.v. cocaine injections during the self-administration component
| f | Buspirone (mg/kg) | Sal | Cocaine (mg/kg per injection)
|
Food 1 | Food 2 | |||
|---|---|---|---|---|---|---|---|---|
| 0.003 | 0.01 | 0.03 | 0.1 | |||||
| RIB9 | 10 (±2) | 28 (±13) | 50 (±2) | 35 (±1) | 28 (±3) | 16 (±0) | 15 (±0) | |
| 0.32 | 0 | 2 | 0 | 0 | 0 | 13 | 12 | |
| 97D105 | 8 (±2) | 14 (±7) | 56 (±4) | 28 (±1) | 11 (±0) | 16 (±0) | 14 (±0) | |
| 0.32 | 1 | 0 | 0 | 1 | 0 | 9 | ||
| 97D113 | 8 (±1) | 3 (±3) | 37 (±4) | 25 (±2) | 17 (±1) | 17 (±0) | 17 (±0) | |
| 0.32 | 11 | 2 | 0 | 0 | 1 | 10 | 16 | |
| 96D155 | 9 (±1) | 26 (±11) | 63 (±1) | 46 (±4) | 36 (±7) | 17 (±0) | 17 (±0) | |
| 0.10 | 19 | 3 | 35 | 0 | 29 | 0 | 17 | |
The numbers of self-administered i.v. injections alone (mean±S.E.M.) are shown for saline (Sal) and for each unit dose of i.v. cocaine (shown in bold) for each monkey.
The last two columns show number of pellets obtained in components of food-maintained behaviour prior to (food 1) and following (food 2) the drug component when saline was available for i.v. self-administration.
The rows in non-bold type show the number of injections and food pellet deliveries in single determinations of the effects of pretreatment with 0.32 mg/kg buspirone in RIB9, 97D105 and 97D113, and with 0.1 mg/kg buspirone in 96D155.