Table 3.
Test Performance Characteristics for Supplemental Hand-Held Ultrasound (HHUS), Automated Whole Breast Ultrasound (ABUS), and MRI
| Study Quality | Sensitivity (95% CI) |
Specificity (95% CI) |
PPV (95% CI) |
NPV (95% CI) |
|---|---|---|---|---|
|
HHUS
| ||||
| Berg, 2012 (25) Good |
0.83 (0.59 to 0.96) |
0.86 (0.85 to 0.88) |
0.03 (0.02 to 0.05) |
1.00 (1.00 to 1.00) |
| Corsetti, 2011 (26) Good |
0.80 (0.65 to 0.91) |
0.95 (0.94 to 0.95) |
0.07 (0.05 to 0.10) |
1.00 (1.00 to 1.00) |
| Hooley, 2012 (29) Fair |
1.00 (0.29 to 1.00) |
0.77 (0.73 to 0.80) |
0.02 (0.01 to 0.06) |
1.00 (0.99 to 1.00) |
| Leong, 2012 (30) Fair |
1.00 (0.16 to 1.00) |
0.79 (0.70 to 0.86) |
0.08 (0.02 to 0.26) |
1.00 (0.96 to 1.00) |
| Youk, 2011 (34) Fair |
1.00 (0.72 to 1.00) |
0.72 (0.67 to 0.76) |
0.08 (0.05 to 0.14) |
1.00 (0.99 to 1.00) |
|
ABUS | ||||
| Kelly, 2010 (37) Fair |
0.68 (0.50 to 0.83) |
0.92 (0.91 to 0.92) |
0.04 (0.03 to 0.06) |
1.00 (1.00 to 1.00) |
|
MRI | ||||
| Berg, 2012 (25) Good |
1.00 (0.59 to 1.00) |
0.78 (0.73 to 0.83) |
0.09 (0.04 to 0.17) |
1.00 (0.99 to 1.00) |
| Kriege, 2006 (38) Good |
0.75 (0.35 to 0.97) |
0.89 (0.87 to 0.90) |
0.03 (0.01 to 0.06) |
1.00 (1.00 to 1.00) |
| Kuhl, 2014 (39) Good |
1.00 (0.29 to 1.00) |
0.94 (0.88 to 0.98) |
0.33 (0.12 to 0.66) |
1.00 (0.96 to 1.00) |
Abbreviations: CI=confidence interval; NPV=negative predictive value; PPV=Positive predictive value