Table 4.
Breast Cancer Detection Outcomes for Adjunctive Hand-Held Ultrasound (HHUS), Automated Whole Breast Ultrasound (ABUS), MRI, and Digital Breast Tomosynthesis (DBT)
| Study Quality | Cancers Detected | Cancer Detection Rate (95% CI) |
Recall Rate (%) (95% CI) |
Biopsy Rate (%)* (95% CI) |
|---|---|---|---|---|
|
HHUS
| ||||
| Berg, 2012 Good (25) |
15/3,414 exams | 4.4 per 1,000 exams (2.5 to 7.2) |
14% (12.7 to 15.1) |
NR |
| Corsetti, 2011 (26) Good |
32/7,224 exams | 4.4 per 1,000 exams (3.0 to 6.2) |
NR | 6% (5.4 to 6.5) |
| Brancato, 2007 (27) Fair |
2/5,227 women | 0.4 per 1,000 women (0 to 1.4) |
2% (1.7 to 2.5) |
1% (0.9 to 1.6) |
| Girardi, 2013 (28) Fair |
22/9,960 women | 2.2 per 1,000 women (1.4 to 3.3) |
NR | NR |
| Hooley, 2012 (29) Fair |
3/648 women | 4.6 per 1,000 women (1.0 to 13.5) |
24% (20.3 to 27.0) |
7% (5.2 to 9.4) |
| Leong, 2012 (30) Fair |
2/106 women | 18.9 per 1,000 women (1.7 to 50.3) |
17%‡ | 13% (7.4 to 21.2)† |
| Parris, 2013 (31) Fair |
10/5,519 women | 1.8 per 1,000 women (0.9 to 3.3) |
NR | 3% (2.8 to 3.8) |
| Venturini, 2013 (32) Fair |
2/826 women | 2.4 per 1,000 women (0.3 to 8.7) |
10% (7.5 to 11.7) |
1% (0.6 to 2.2) |
| Weigert, 2012 (33) Fair |
25/8,647 women | 2.9 per 1,000 women (1.9 to 4.3) |
14% (13.1 to 14.5) | 5% (4.4 to 5.3) |
| Youk, 2011 (34) Fair |
11/446 exams | 24.7 per 1,000 exams (12.4 to 43.7) |
14% (10.6 to 17.2) |
11% (8.2 to 14.3) |
|
ABUS | ||||
| Brem, 2015 (35) Fair |
30/15,318 women | 1.9 per 1,000 exams (1.3 to 2.8) |
14% (12.9 to 14.0) |
4% (3.4 to 4.0) |
| Giuliano, 2013 (36) Fair |
DM+ABUS: 52/3418 women DM: 19/4076 women |
DM+ABUS: 15.21 per 1,000 women (11.4 to 19.9) DM: 4.7 per 1,000 women (2.8 to 7.3) |
2% (1.1 to 2.0) |
NR |
| Kelly, 2010 (37) Fair |
23/6425 exams |
3.6 per 1,000 exams (2.3 to 5.4) |
9% (8.0 to 9.4) |
NR |
|
MRI | ||||
| Berg, 2012 (25) Good |
7/334 exams | 21 per 1,000 exams (8.5 to 42.7) |
23% (18.9 to 28.3) |
NR |
| Kriege, 2006 (38) Good |
6/1723 exams | 3.5 per 1,000 exams (1.3 to 7.6) |
12 % (10.0 to 13.1) |
NR |
| Kuhl, 2014 (39) Good |
3/105 women | 28.6 per 1,000 women (5.9 to 81.2) |
9% (4.0 to 15.7) |
NR |
|
DBT | ||||
| Ciatto, 2013 (40) | DBT+DM: 8/1215 exams DM: 5/1215 exams |
DBT+DM: 6.6 per 1,000 exams (2.9 to 12.9) DM: 4.1 per 1,000 exams (1.3 to 9.6) |
DBT+DM: 7% (5.2 to 8.1) DM only: 7% (5.8 to 8.8) |
NR |
| Haas, 2013 (41) | NR | NR | DBT+DM: 10% (8.6 to 10.9) DM: 17% (15.0 to 18.2) |
NR |
| McCarthy, 2014 (42) Fair |
DBT+DM: 35/5056 exams DM: 18/3489 exams |
DBT+DM: 6.9 per 1,000 exams (4.8 to 9.6) DM: 5.2 per 1,000 exams (3.1 to 8.1) |
DBT+DM: 11% (10.0 to 11.7) DM: 13% (11.7 to 14.0) |
NR |
| Rose, 2013 (43) Fair |
DBT+DM: 25/4666 exams DM: 28/7009 exams |
DBT+DM: 5.4 per 1,000 exams (3.5 to 7.9) DM: 4.0 per 1,000 exams (2.7 to 5.8) |
DBT+DM: 7% (6.2 to 7.7) DM: 9% (8.4 to 11.0) |
NR |
*
Biopsy rate includes needle aspiration, core needle, and open biopsies
†
Data are based on the 106 women with complete follow-up (out of 141 total)
Abbreviations: CI=confidence interval; DM=digital mammography; NR=not reported