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. 2016 Sep 16;6(11):3663–3670. doi: 10.1534/g3.116.034363

Figure 3.

Figure 3

The CPD and S4 domains mediate stability of LIN-12(intra) in VPCs but do not mediate stability of LIN-12(intra) in VPC descendants [Pn.p (VPCs), Pn.px (their daughters), and Pn.pxx (their granddaughters)]. Mutation of either the CPD or S4 domain prevents degradation of LIN-12(intra), increasing LIN-12(intra) activity and protein stabilization in the VPCs. Neither the CPD nor S4 domain contain the regulatory information for protein downregulation in the VPC descendants, and loss of sel-10 does not affect LIN-12(intra-S4mut) stabilization in the VPC descendants. CPD, Cdc4 phosphodegron; GFP, green fluorescent protein.