Table 2. KEGG pathways underlying eQTL biological effects in the white adipose tissue transcriptome in the GK × BN F2 cross.
| Congenics | |||||||
|---|---|---|---|---|---|---|---|
| Rank | KEGG ID | P Value | Count | Size | Term | Upregulation | Downregulation |
| 1 | 5332 | <0.01 | 17 | 34 | Graft vs. host disease | — | — |
| 2 | 4145 | <0.01 | 41 | 128 | Phagosome | — | — |
| 3 | 4940 | <0.01 | 18 | 39 | Type 1 diabetes mellitus | — | — |
| 4 | 5416 | <0.01 | 24 | 61 | Viral myocarditis | — | GK.BN7a, 8a, 10_7a |
| 5 | 4612 | <0.01 | 22 | 58 | Antigen processing and presentation | BN.GK7a | BN.GK1p; GK.BN10_7a |
| 6 | 5330 | <0.01 | 16 | 37 | Allograft rejection | — | — |
| 7 | 5320 | <0.01 | 16 | 39 | Autoimmune thyroid disease | — | — |
| 8 | 4514 | <0.01 | 29 | 92 | Cell adhesion molecules | — | BN.GK1v,10a; GK.BN8a, 10_7a |
| 9 | 1100 | <0.01 | 167 | 798 | Metabolic pathways | — | — |
| 10 | 5140 | <0.01 | 19 | 53 | Leishmaniasis | BN.GK7a, 7d | GK.BN10_7a |
| 11 | 5322 | <0.01 | 19 | 59 | Systemic lupus erythematosus | — | — |
| 12 | 380 | <0.01 | 11 | 27 | Tryptophan metabolism | — | — |
| 13 | 5150 | 0.01 | 12 | 33 | Staphylococcus aureus infection | — | — |
| 14 | 250 | 0.01 | 9 | 22 | Alanine, aspartate, and glutamate metabolism | — | — |
| 15 | 280 | 0.01 | 12 | 34 | Valine, leucine, and isoleucine degradation | BN.GK5a; GK.BN7a, 8a, 10_7a | BN.GK7d |
| 16 | 360 | 0.01 | 5 | 9 | Phenylalanine metabolism | — | — |
| 17 | 350 | 0.01 | 7 | 16 | Tyrosine metabolism | — | — |
| 18 | 650 | 0.02 | 7 | 17 | Butanoate metabolism | — | — |
| 19 | 71 | 0.02 | 11 | 33 | Fatty acid metabolism | GK.BN7a, 8a | — |
| 20 | 790 | 0.02 | 4 | 7 | Folate biosynthesis | — | — |
| 21 | 5144 | 0.02 | 11 | 34 | Malaria | — | — |
| 22 | 511 | 0.02 | 6 | 14 | Other glycan degradation | — | — |
| 23 | 4650 | 0.02 | 19 | 70 | Natural killer cell-mediated cytotoxicity | BN.GK7a, 8b | GK.BN7a, 8a, 10_7a |
| 24 | 4640 | 0.02 | 15 | 52 | Hematopoietic cell lineage | — | GK.BN10_7a |
| 25 | 982 | 0.03 | 13 | 44 | Drug metabolism – cytochrome P450 | GK.BN7a, 8a, 10_7a | — |
| 26 | 270 | 0.03 | 9 | 27 | Cysteine and methionine metabolism | BN.GK1v; GK.BN7a | — |
| 27 | 4975 | 0.03 | 9 | 27 | Fat digestion and absorption | — | — |
| 28 | 450 | 0.04 | 5 | 12 | Selenocompound metabolism | — | — |
| 29 | 4970 | 0.05 | 15 | 57 | Salivary secretion | — | — |
| 30 | 4512 | 0.05 | 15 | 57 | Extra-cellular matrix-receptor interaction | — | BN.GK1b, 1q, 1v, 5c, 10a; GK.BN8a, 10_7a |
Data were analyzed with sex and cross as additive covariates. Congenic strains showing upregulation or downregulation in pathways identified in F2 hybrids are listed. Details of pathways can be found at www.genome.jp/kegg/.