Table 1.
Selected FDA-approved protein therapeutics
Data obtained from Leader et al.39 and www.fda.gov
| Trade name(s) | Therapeutic use | Administration route | Description |
|---|---|---|---|
| Humulin, Novolin | Diabetes mellitus | Injection (subcutaneous) | Insulin, recombinant human Hormone that regulates blood glucose |
| Afrezza, Exubera | Diabetes mellitus | Inhalation (powder) | Insulin, recombinant human Hormone that regulates blood glucose |
| Genotropin, Humatrope, Nutropin, Saizen, Zomacton, Zorbtive | Growth deficiencies | Injection (subcutaneous or intramuscular) | Somatropin (human growth hormone) Hormone that has anabolic effect |
| Adynovate, Benefix, Bioclate, Eloctate, Novoeight, Nuwiq, Recombinate | Hemophliia | Injection (intravenous) | Antihemophilic factor (factor VIII, factor IX) Acts as a coagulation factor to stem bleeding |
| Elaprase | Hunter symdrome (MPS II) | Injection (intravenous) | Idursulfase Cleaves the GAGs heparan sulfate and dermatan sulfate, preventing their buildup |
| Follistim | Fertility | Injection (subcutaneous or intramuscular) | Human follicle stimulating hormone (FSH) Aids ovulation, generally used with HCG |
| Ovidrel | Fertility | Injection (subcutaneous or intramuscular) | Human chorionic gondadotropin (HCG) Aids ovulation, generally used with FSH |
| Avastin | Cancer, anti-angiogenesis | Injection (intravenous, intravitreal) | Bevacizumab Monoclonal antibody that targets VEGF-A |
| Herceptin | Cancer | Injection (intravenous) | Trastuzumab Monoclonal antibody that targets HER2/Neu |
| Humira | Rheumatoid Arthiritis | Injection (subcutaneous) | Adalimumab Monoclonal antibody that targets TNF-α |