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. Author manuscript; available in PMC: 2017 Jul 14.
Published in final edited form as: J Med Chem. 2016 Jul 1;59(13):6531–6546. doi: 10.1021/acs.jmedchem.6b00760

Fig. 11.

Fig. 11

Inhibitor 32 is efficacious against latent T. gondii infection. 32 reduced the number of T. gondii cysts per brain compared to a vehicle control. Five weeks after being inoculated by the ME49 T. gondii strain, mice were treated once daily for 14 days via oral gavage with 30 mg/kg of 32 or PEG400 vehicle control. A group of mice was also treated twice–days 1 and 7–via oral gavage with 105 mg/kg of 32. Two weeks after the final drug treatment, mice were sacrificed and the number of brain cysts was determined. The number of cysts per brain was >85% lower for both dosing regimens of 32 relative to a vehicle control. Bars represent the mean and the standard error of the mean. PEG = polyethylene glycol; mpk = mg/kg.