Scheme 3.
a) alkyl halide or alkyl mesylate, Cs2CO3, DMF, 80 °C; b) epoxide, NaH2PO4:K2CO3 (1:1), DMF, 80 °C; c) aryl boronate ester, K3PO4 or Na2CO3, PdCl2(dppf) or Pd(PPh3)4, 1,4-Dioxane:H2O or DME:H2O, 80 °C (microwave).
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