Table 4.

Solubility (in phosphase-buffered saline, pH= 6.5) and PK properties of the most potent and selective TgCDPK1 inhibitors dosed at 10 mg/kg PO to mice.

	Solubility (μM)	Tmax (min)	Cmax (μM)	AUCo->inf (μM.min)	Half life (min)	clearance (mL/min)
1	82	120	0.75 ±0.15	430 ±58	233 ±26	0.7
8	48	50	0.89 ±0.17	94 ±51	68 ±64	2.5
17	54	200	0.26 ±0.04	128 ± 53	223 ±182	1.8
29	17	30	0.88 ±0.23	67 ±60	50 ±73	110
31	>100	50	5.2 ±1.0	850 ± 411	114 ±115	0.2
32	>100	320	13 ±1	13700 ±1500	1190 ±510	0.2
33	>100	560	7.8 ±1.4	16600 ±4300	1110 ±400	0.3
34	6.2	40	0.39 ±0.16	31 ±8	40 ±5	6.7
35	8.0	30	3.9 ±1.1	3.9 ±1.1	41 ±21	21