. Author manuscript; available in PMC: 2017 Jul 14.

Published in final edited form as: J Med Chem. 2016 Jul 1;59(13):6531–6546. doi: 10.1021/acs.jmedchem.6b00760

Table 5.

In vivo pharmacokinetic parameters of 32 and 33 in rats following IV administration of 5 mg/kg. Data is shown as mean and range between animals.

	AUC (hμ mol/L)*	CL (mL/hr/kg)	V_ss (L/kg)	T_1/2 (hr)
32	167 (160–175)	77 (73–80)	0.91(0.89–0.93)	9.6 (9.5–9.7)
33	45 (31–59)	310 (216–412)	5.8 (4.1–7.5)	13 (12.6–13.4)