. Author manuscript; available in PMC: 2017 Jul 14.

Published in final edited form as: J Med Chem. 2016 Jul 1;59(13):6531–6546. doi: 10.1021/acs.jmedchem.6b00760

Table 7.

In vivo pharmacokinetic parameters of 32 following IV and PO administration of 1 mg/kg to dogs and monkeys (n=3 for each). Data is show as mean and standard deviation.

	AUC (hμ mol/L)*	CL (mL/hr/kg)	Vss (L/kg)	t1/2 (hr)
Dogs
IV	11200 ±1100	90 ±10	1.7 ±0.1	13.2
PO	9620 ±1350
Monkeys
IV	8720 ±3400	130 ±50	1.8 ±0.3	9.6
PO	5730 ±1500