Table 1. Echocardiographic functional analysis for WT and MFS mice.
| Parameter (units) | 6 month group | 12 month group | ||||
|---|---|---|---|---|---|---|
| WT | MFS | p | WT | MFS | p | |
| Body weight (g) | 39.1 ± 1.0 | 37.6 ± 1.1 | 0.88 | 41.9 ± 1.3 | 37.2 ± 2.2 | 0.14 |
| Heart Rate (bpm) | 434 ± 21 | 432 ± 10 | 0.99 | 453 ± 10 | 462 ± 18 | 0.97 |
| ESV (N) (μl/g) | 0.76 ± 0.08 | 0.81 ± 0.08 | 0.98 | 0.78 ± 0.07 | 0.62 ± 0.11 | 0.41 |
| EDV (N) (μl/g) | 1.96 ± 0.09 | 2.37 ± 0.14 | 0.13 | 1.97 ± 0.09 | 1.90 ± 0.17 | 0.98 |
| SV (N) (μl/g) | 1.20 ± 0.05 | 1.56 ± 0.09 | 0.04* | 1.20 ± 0.07 | 1.29 ± 0.13 | 0.88 |
| EF (%) | 62 ± 3 | 66 ± 2 | 0.75 | 61 ± 2 | 68 ± 3 | 0.33 |
| FS (%) | 33 ± 2 | 36 ± 1 | 0.74 | 32 ± 1 | 38 ± 2 | 0.29 |
| CO (N) (ml/min/g) | 0.52 ± 0.03 | 0.68 ± 0.05 | 0.09 | 0.54 ± 0.03 | 0.60 ± 0.06 | 0.81 |
All parameter measurements are presented as Means ± SEM (n = 8 mice).
* indicates p < 0.05.
N, normalized with body weight. ESV End systolic volume; EDV End diastolic volume; SV Stroke volume; EF Ejection fraction; FS Fractional shortening; CO cardiac output.