Table 5. Significant independent predictors of OS and LFS in patients treated with hypomethylating agents (n = 377).
| Variables | HR for OS (95% CI) | p-value | HR for LFS (95% CI) | P-value |
|---|---|---|---|---|
| Translocation | ||||
| No | 1 | 1 | ||
| Yes | 1.71 (1.04–2.82) | 0.03 | 1.86 (1.17–2.95) | <0.01 |
| MK | ||||
| No | 1 | - | ||
| Yes | 1.68 (1.09–2.60) | 0.02 | - | - |
| IPSS-R | ||||
| Very High | 1 | 1 | ||
| High | 0.86 (0.57–1.31) | 0.49 | 0.67 (0.47–0.97) | 0.03 |
| Intermediate | 0.54 (0.34–0.85) | < 0.01 | 0.39 (0.27–0.58) | <0.01 |
| Low | 0.22 (0.12–0.39) | < 0.01 | 0.16 (0.10–0.27) | <0.01 |
| HSCT | ||||
| No | 1 | 1 | ||
| Yes | 0.43 (0.27–0.67) | < 0.01 | 0.37 (0.24–0.57) | <0.01 |
Abbreviations: HR, hazard ratio; CI, confidence interval; OS, overall survival; IPSS-R, revised International Prognostic Scoring System; CK, complex karyotype; HSCT, hematopoietic stem cell transplantation.