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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Antiviral Res. 2016 Apr 7;131:61–65. doi: 10.1016/j.antiviral.2016.04.003

Table 2.

Activities of test compounds against EV-D68 (US/KY/14-18953 strain) by virus yield reduction assays in RD cells.

Compound EC90a (μM) ± SD SI b
3-Deazaguanine 8.0 ± 1.1 45
Enviroxime 0.61 ± 0.08 156
Guanidine HCl 60 ± 1.3 64
KCN-2,2’-epi-19 0.14 ± 0.03 14
KCN-19 0.27 ± 0.03 13
KCN-21 0.024 ± 0.002 100
Pirodavir 106 ± 12 <1
Pleconaril 0.21 ± 0.05 54
Ribavirin 93 ± 23 12
Rupintrivir 0.004 ± 0.002 33,500
a

90% (1 log10) reduction of virus yield; mean ± SD calculated from three independent assays.

b

Selectivity index (CC50 [from Table 1] / EC90).