Table 2.
Activities of test compounds against EV-D68 (US/KY/14-18953 strain) by virus yield reduction assays in RD cells.
Compound | EC90a (μM) ± SD | SI b |
---|---|---|
3-Deazaguanine | 8.0 ± 1.1 | 45 |
Enviroxime | 0.61 ± 0.08 | 156 |
Guanidine HCl | 60 ± 1.3 | 64 |
KCN-2,2’-epi-19 | 0.14 ± 0.03 | 14 |
KCN-19 | 0.27 ± 0.03 | 13 |
KCN-21 | 0.024 ± 0.002 | 100 |
Pirodavir | 106 ± 12 | <1 |
Pleconaril | 0.21 ± 0.05 | 54 |
Ribavirin | 93 ± 23 | 12 |
Rupintrivir | 0.004 ± 0.002 | 33,500 |
90% (1 log10) reduction of virus yield; mean ± SD calculated from three independent assays.
Selectivity index (CC50 [from Table 1] / EC90).