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. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Antiviral Res. 2016 Apr 7;131:61–65. doi: 10.1016/j.antiviral.2016.04.003

Table 3.

Antiviral activities and toxicities of three inhibitors against EV-D68 in different cell lines by neutral red assay.

	Enviroxime			Guanidine HCl			Pirodavir

Cell Line	EC₅₀^a	CC₅₀^b	SI^c	EC₅₀	CC₅₀	SI	EC₅₀	CC₅₀	SI
A549	0.77 ± 1.1	68 ± 13	89	32 ± 4.8	2990 ± 500	93	11 ± 7.2	140 ± 33	13
HeLa-Ohio-1	1.7 ± 0.72	78 ± 24	45	66 ± 22	3040 ± 79	46	6.1 ± 2.8	33 ± 6.1	5.3
RD	0.27 ± 0.23	66 ± 28	240	76 ± 28	3960 ± 510	52	8.1 ± 3.9	32 ± 18	3.9

^a

50% effective concentration (μM) ± SD (≥3 independent determinations) against EV-D68/US/KY/14-18953.

^b

50% cytotoxic concentration (μM) ± SD (≥3 independent determinations) in stationary cell monolayers.

^c

Selectivity index (CC₅₀ / EC₅₀).