Fig 5. Cognition and beta in MPTP period.

MPTP lesion does not impair cognitive control. Cognitive control remains significantly represented in the beta power of the delay. A. Change in choice optimality over MPTP treatment. Monkeys remain near optimal throughout treatment. Change with respect to BL only occurs when non-optimal choices reduce, meaning performance improved. B. Shannon entropy of the first two choices of the search phase during the MPTP period. The search strategy remains unaffected by MPTP treatment, never varying significantly from BL. C. Model-derived coefficient for the cognitive control factor (response to previous feedback) during MPTP period. The solid lines indicate that the factor makes a significant contribution to the model at every point in the MPTP period, so the coefficient remains positive and significant throughout, whilst the colored bars indicate where the coefficient changes with respect to BL. This confirms that cognitive control continues to be represented by beta power throughout the lesion, although the coefficient weakens towards the end of the protocol. Inset: As for Fig 2D, but fitted on data from the full dose—beta power represents cognitive control in the same manner after MPTP treatment as it did before. Colored bars: comparison to BL bootstrap, p < 0.01.