Author response image 1. Impact of Ra value on the quality of the fit of the theoretical versus the experimental transients.
(a) Experimental (black trace) and best theoretical fit (green trace) as in Figure 1A. (b) Zoom in on the green square in a. (c–e) Same as in b, but with Raconstrained to 100, 200 and 300 Ω•cm correspondingly. Note the deviation of the fit from the experimental trace in the first couple of ms in c and e. Parameters resulted for the various optimization:
c. Ra = 100 Ω•cm (constrained), Cm= 0.42 μF/cm2, Rm= 41,315 Ω•cm2; d. Ra = 200 Ω•cm (constrained), Cm= 0.46 μF/cm2, Rm= 38,299 Ω•cm2 ;e. Ra = 300 Ω•cm (constrained), Cm= 0.50 μF/cm2, Rm= 36,372 Ω•cm2.