Table 2.

Multisystemic Nature of EDS-HT.

System	Manifestations
Cardiovascular	Aortic regurgitation, aortic root dilatation, mitral valve prolapse, mitral regurgitation, tricuspid regurgitation, Reynaud phenomenon
Autonomic Nervous System	Palpitations, dizziness, pre-syncope, syncope
Gastrointestinal	Gastroesophageal reflux, dyspepsia, gastritis, delayed gastric emptying, irritable bowel syndrome
Hematologic	Easy bruising, bleeding tendency, prolonged bleeding time, oral mucosal bruises, menometrorrhagia
Ocular	Myopia, strabismus
Gynecologic	Dysmenorrhea, menorrhagia, dyspareunia, uterine prolapse
Urologic	Constipation, fecal soiling, urinary tract infections, urinary incontinence, bladder prolapse, rectal prolapse,
Obstetric	Short labor and delivery, premature rupture of membranes, pelvic pain, varicose veins, worsening of dysautonomia during pregnancy, postpartum hemorrhage, complicated perineal wounds
Neurologic	Headache, local anesthesia failure, postural instability, increased frequency of falls, impaired proprioceptive acuity, Chiari 1 type 1
Psychiatric	Kinesiophobia, anxiety, depression