Figure 12. Genome conformation models of major groups of flaviviruses.
Sequences involved in terminal interactions are shown in red. The 5′ RNA structures that are immediately downstream of SLA elements and consistently involved in genome cyclization are indicated by red arrows. The typical UFS element in MBFVs is shown in blue. The demonstrated structures are based on DENV4 for the MBFVs; tick-borne encephalitis virus (TBEV) for TBFVs; Wesselsbron virus (WESSV) for the YFV clade of the MBFVs and RBV for the NKVs. The kissing loop interaction identified recently in the tick-borne group (Tsetsarkin et al., 2016) is labeled by green letters (KL).
Figure 12—figure supplement 1. Terminal genomic RNA structures of the MBFV group.
The demonstrated sequence was based on DENV4. Sequences involved in genome cyclization are highlighted in yellow. The gray regions are not included in the demonstration of Figure 12. The mfold software and VARNA application were utilized to generate the structural models.
Figure 12—figure supplement 2. Terminal genomic RNA structures of the YFV clade in the MBFV group.
The demonstrated sequence was based on WESSV. Sequences involved in genome cyclization are highlighted in yellow. The gray regions are not included in the demonstration of Figure 12. The mfold software and VARNA application were utilized to generate the structural models.
Figure 12—figure supplement 3. Terminal genomic RNA structures of the TBFV group.
The demonstrated sequence was based on TBEV. Sequences involved in genome cyclization are highlighted in yellow. The gray regions are not included in the demonstration of Figure 12. The mfold software and VARNA application were utilized to generate the structural models.
Figure 12—figure supplement 4. Terminal genomic RNA structures of the NKV group.
The demonstrated sequence was based on RBV. Sequences involved in genome cyclization are highlighted in yellow. The gray regions are not included in the demonstration of Figure 12. The mfold software and VARNA application were utilized to generate the structural models.