Table 2.
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Parameter | Sham | AAV9-Con | AAV9-JPH2 | P-Value | P-Value | P-Value |
| ||||||
n = 10 | n = 13 | n = 11 | Sham vs. AAV9-Con | Sham vs. AAV9-JPH2 | AAV9-Con vs. AAV9-JPH2 | |
HR (bpm) | 565 ± 7.30 | 586 ± 9.01 | 581 ± 9.21 | 0.22 | 0.43 | 0.91 |
EF (%) | 69.7 ± 0.83 | 29.4 ± 2.09 | 47.2 ± 2.93 | < 0.0001 | < 0.0001 | < 0.0001 |
FS (%) | 38.5 ± 0.63 | 13.8 ± 1.05 | 23.7 ± 1.75 | < 0.0001 | <0.0001 | <0.0001 |
ESD (mm) | 2.19 ± 0.05 | 4.13 ± 0.19 | 3.24 ± 0.14 | < 0.0001 | 0.0001 | 0.0004 |
EDD (mm) | 3.56 ± 0.06 | 4.77 ± 0.17 | 4.23 ± 0.10 | < 0.0001 | 0.003 | 0.01 |
LVAW;d (mm) | 0.72 ± 0.01 | 0.87 ± 0.04 | 0.97 ± 0.03 | 0.003 | < 0.0001 | 0.06 |
LVAW;s (mm) | 0.98 ± 0.02 | 1.03 ± 0.05 | 1.16 ± 0.04 | 0.69 | 0.01 | 0.05 |
LVID;d (mm) | 3.53 ± 0.06 | 4.74 ± 0.16 | 4.16 ± 0.10 | < 0.0001 | 0.01 | 0.01 |
LVID;s (mm) | 2.29 ± 0.05 | 4.13 ± 0.18 | 3.27 ± 0.14 | < 0.0001 | 0.0003 | 0.001 |
LVPW;d (mm) | 0.81 ± 0.02 | 0.99 ± 0.04 | 1.13 ± 0.06 | 0.02 | < 0.0001 | 0.07 |
LVPW;s (mm) | 1.24 ± 0.02 | 1.2 ± 0.05 | 1.45 ± 0.07 | 0.82 | 0.03 | 0.004 |
EDD: end-diastolic diameter; EF: ejection fraction; ESD: end-systolic diameter; FS: fractional shortening, HR: heart rate, LVAW;d/LVAW;s: left ventricular anterior wall in diastole/systole; LVID;d/LVID;s: left ventricular internal diameter in diastole/systole; LVPW;d/LVPW;s: left ventricular posterior wall in diastole/systole.