Table 2.

Echocardiographic measurements for sham, AAV9-Con and AAV9-JPH2 treated TAC mice at 9 weeks post TAC.

Parameter	Sham	AAV9-Con	AAV9-JPH2	P-Value	P-Value	P-Value
	n = 10	n = 13	n = 11	Sham vs. AAV9-Con	Sham vs. AAV9-JPH2	AAV9-Con vs. AAV9-JPH2
HR (bpm)	565 ± 7.30	586 ± 9.01	581 ± 9.21	0.22	0.43	0.91
EF (%)	69.7 ± 0.83	29.4 ± 2.09	47.2 ± 2.93	< 0.0001	< 0.0001	< 0.0001
FS (%)	38.5 ± 0.63	13.8 ± 1.05	23.7 ± 1.75	< 0.0001	<0.0001	<0.0001
ESD (mm)	2.19 ± 0.05	4.13 ± 0.19	3.24 ± 0.14	< 0.0001	0.0001	0.0004
EDD (mm)	3.56 ± 0.06	4.77 ± 0.17	4.23 ± 0.10	< 0.0001	0.003	0.01
LVAW;d (mm)	0.72 ± 0.01	0.87 ± 0.04	0.97 ± 0.03	0.003	< 0.0001	0.06
LVAW;s (mm)	0.98 ± 0.02	1.03 ± 0.05	1.16 ± 0.04	0.69	0.01	0.05
LVID;d (mm)	3.53 ± 0.06	4.74 ± 0.16	4.16 ± 0.10	< 0.0001	0.01	0.01
LVID;s (mm)	2.29 ± 0.05	4.13 ± 0.18	3.27 ± 0.14	< 0.0001	0.0003	0.001
LVPW;d (mm)	0.81 ± 0.02	0.99 ± 0.04	1.13 ± 0.06	0.02	< 0.0001	0.07
LVPW;s (mm)	1.24 ± 0.02	1.2 ± 0.05	1.45 ± 0.07	0.82	0.03	0.004

EDD: end-diastolic diameter; EF: ejection fraction; ESD: end-systolic diameter; FS: fractional shortening, HR: heart rate, LVAW;d/LVAW;s: left ventricular anterior wall in diastole/systole; LVID;d/LVID;s: left ventricular internal diameter in diastole/systole; LVPW;d/LVPW;s: left ventricular posterior wall in diastole/systole.