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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: J Immunol. 2016 Sep 19;197(8):3260–3270. doi: 10.4049/jimmunol.1600033

Figure 2. IL-6 is required for optimal heterosubtypic protection.

Figure 2

WT or Il6−/− mice on a BALB/c background were primed with a low dose (500 EID50 = 0.1 LD50 for WT mice) of A/PR8 (H1N1). After 45 days mice were challenged with a 150 LD50 dose of A/Philippines (H3N2) virus and (a) morbidity and (b) survival monitored (n=5 mice/group; one of 2 experiments). Viral titers (c) from lungs of A/PR8-primed WT or Il6−/− mice (n=4 mice/group), or unprimed WT control mice (n=3) were assessed on the stated dpi after 150 A/Phil challenge. Data is representative of one of two experiments. The dashed line in (c) represents sensitivity cutoff of the assay.