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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: J Immunol. 2016 Sep 21;197(8):3076–3085. doi: 10.4049/jimmunol.1600197

Table 2.

Pathway analysis determination of biological pathways elevated in RAGE+ versus RAGE- T1D T cells.

Enriched Biological Pathways – RAGE+ T1D T cells P-value
Apoptosis and survival_Anti-apoptotic TNFs/NF-κB/Bcl-2 pathway 1.967E-06
Immune response_Naive CD4+ T cell differentiation 3.846E-06
Immune response_TNF-R2 signaling pathways 6.334E-05
Signal transduction_NF-κB activation pathways 1.033E-04
Immune response_IL-6 signaling pathway 3.699E-04
Immune response_IL-12-induced IFN-gamma production 5.757E-04
Immune response_IL-4 signaling pathway 1.034E-03
Immune response_IL-12 signaling pathway 3.866E-03
Development_PDGF signaling via STATs and NF-κB 7.332E-03
Immune response_Th17 cell differentiation 8.698E-03

Differences in gene expression in RAGE+ and RAGE- T cells, within the same individual, were used to identify biologic pathways that differ with MetaCORE (Thompson Reuters). The ten most altered T lymphocyte pathways in T1D T cells are ordered based on statistical significance (P-value).