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Number of ligands required to obtain a productive response CN = 1 calculated under steady-state conditions as a function of their dissociation times for the different models shown in Figure 4. (A) Black, basic KPR model; (B) green, KPR (McKeithan’s modification); (C) blue, induced rebinding with N = 20; (D) purple, induced rebinding with N = 25; (E) red, our model: antigenic pMHC; (F) cyan, our model: self-pMHC. Other conditions as in Figure 4.
