Table 2.

Dependence of the productive signaling response C_N on N.

	Number of ligands per cella
N	CN (foreign pMHC)	CN (self-pMHC)	CN (KPR model)
4	10447.3	681.7	3946.7
6	8313.9	78.3	1754.1
8	6677.1	8.3	779.6
10	5391.1	0.8	346.5
12	4368.3	8.2 × 10−2	154.0
14	3548.4	7.8 × 10−3	68.4
16	2888.1	7.3 × 10−4	30.4
18	2354.1	6.7 × 10−5	13.5
20	1921.3	6.1 × 10−6	6.0

The dissociation time for the three types of pMHCs is 2 s. Other conditions as in Figure 3.

^aValues of C_N (productive signaling response) under steady-state conditions; P_T = 10⁷, T_T = 2 × 10⁴, so that C_N is bounded by T_T.