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Schematic summary of IS induced ADMSCs functionally incompetence via MEF2A, MEF2D and CACNA1S. The malfunction of ADMSCs subsequently resulted in declined the capacity of stem cells proliferation, migration and wound healing power. Meanwhile, cell apoptosis process has been progressively escalated concomitant with cells blocked at G1 phase. These features eventually hold back the regeneration capacity of chronic kidney disease patients
