FIG 8 .
Identification of IFN-γ- and/or IFN-α-inducible genes in primary astrocytes and brain of T. gondii-infected GFAP-Cre STAT1f/f mice. RT-PCR was used to estimate the levels of candidate transcripts in the brain of control and GFAP-Cre STAT1f/f mice infected for 25 days. Transcript levels were normalized to the expression of β-actin. These graphs are means ± standard errors of the means of transcript levels from experimental groups of 4 mice each. A paired analysis of the infected control and GFAP-Cre STAT1f/f mice for the interferon-induced targets Gbp2, Gbp3, Cxcl10, Cd274, Irgm2, Igtp, Ifi47, Tgtp1, Gbp5, Cxcl9, Irf1, and Gbp10 revealed that this group was significantly different (P = 0.045). *, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.001.