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. 2016 Nov 8;7(6):e01915-16. doi: 10.1128/mBio.01915-16

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Copyright © 2016 von Schaewen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Evolution of mtHCV during long-term replication in uPA-SCID mice repopulated with human hepatocytes. (a) Mice were inoculated with an equal dose of wild-type HCV and mtHCV. Virus plasma levels were determined at the indicated time points postinoculation. (b and c) Evolution of mtHCV sequence during chronic infection in mice. The E1-E2-p7 coding region of the virus inoculum (b) and of the virus population circulating 8 weeks postinoculation (c) was amplified and sequenced using the Roche 454 platform. The x axis represents nucleotide position relative to the reference sequence. The y axis represents nucleotide coverage across the E1-E2-p7 coding region with synonymous (dS) and nonsynonymous (dN) single nucleotide polymorphism (SNP) frequencies in the viral population relative to the reference sequence highlighted. The mtHCV-specific adaptations L216F, V388G, and M405T are marked with red asterisks.